3'phosphoadenylylsulfate Galactosylceramide 3'sulfotransferase

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Expression 5 Pathology 6 More General Terms 7 Internet Database 8 References

Function

• catalyzes sulfation of membrane glycolipids
• seems to prefer beta- glycosides at the non- reducing termini of sugar chains attached to a lipid moiety
• catalyzes synthesis of galactosylceramide sulfate ( sulfatide), a major lipid component of the myelin sheath & of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes ( putative)
• also acts on lactosylceramide, galactosyl 1- alkyl-2-sn-glycerol & galactosyl diacylglycerol ( in vitro)
• lipid metabolism; sphingolipid metabolism
  

• 3'-phosphoadenylyl sulfate + galactosylceramide = adenosine 3',5'-bisphosphate + galactosylceramidesulfate
  
• 3'-phosphoadenylyl sulfate + monogalactosylalkylacylglycerol = adenosine 3',5'-bisphosphate + monogalactosylalkylacylglycerol sulfate

Structure

• belongs to the galactose-3-O- sulfotransferase family

Compartment

• Golgi membrane; single-pass type 2 membrane protein ( putative)

Expression

• expressed in kidney proximal tubule, gastric mucosa

Pathology

• expressed in adenocarcinomas
• highly expressed in renal cell carcinoma cell lines

More General Terms

• sulfotransferase
• glycoprotein
• membrane protein

Internet Database

Entrez gene: 9514
Kegg: [1]
OMIM: 602300
UniProt: [2]

References

1. UniProt [3]
2. GGDB; Note: glycogene database [4]

galactosylceramide sulfotransferase; galcer sulfotransferase; 3'-phosphoadenosine-5'-phosphosulfate:galcer sulfotransferase; 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase; cerebroside sulfotransferase (GAL3ST1, CST)