1 Acyl Sn Glycerol 3 Phosphate Acyltransferase Zeta

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Expression 5 More General Terms 6 Internet Database 7 References

Function

• de novo phospholipid biosynthesis, 2nd step
• converts lysophosphatidic acid into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone
• HXXXXD motif is essential for acyltransferase activity, binding site for phosphate moiety glycerol-3-phosphate (putative)

* Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate  <--> 
*               CoA + 1,2-diacyl-sn-glycerol 3-phosphate

Structure

• HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity). -!- SIMILARITY: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family

Compartment

• membrane

Expression

• expressed in skeletal muscle, heart, testis > lung

More General Terms

• 1-acyl-sn-glycerol-3-phosphate acyltransferase
• glycoprotein
• membrane protein

Internet Database

OMIM: 608143
UniProt: [1]

References

UniProt [2]

1-acyl-sn-glycerol-3-phosphate acyltransferase zeta (1-AGP acyltransferase 6, 1-AGPAT 6, lysophosphatidic acid acyltransferase zeta, LPAAT-zeta, AGPAT6)