1 Acyl Sn Glycerol 3 Phosphate Acyltransferase Theta

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Expression 5 More General Terms 6 Internet Database 7 References

Function

• catalyzes 1st step during de novo synthesis of triacylglycerol
• converts lysophosphatidic acid into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone
• overexpression activates the mTOR pathway
  

• Acyl-CoA + 1-acyl-sn-glycerol 3- phosphate <--> CoA + 1,2-diacyl-sn-glycerol 3- phosphate
  
• Inhibition:

• inhibited by N-ethylmaleimide (NEM)

Structure

• belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family
• HXXXXD motif

• essential for acyltransferase activity
• may constitute binding site for phosphate moiety of glycerol-3-phosphate

Compartment

• endoplasmic reticulum membrane

Expression

• widely expressed
• expressed in liver, kidney, testis, brain, heart, skeletal muscle, thyroid, prostate, thymus, placenta
• expressed lung & adipose tissue

More General Terms

• 1-acyl-sn-glycerol-3-phosphate acyltransferase
• membrane protein

Internet Database

UniProt: [1]

References

UniProt [2]

1-acyl-sn-glycerol-3-phosphate acyltransferase theta (lysophosphatidic acid acyltransferase theta, LPAAT-theta, acyl-CoA:glycerol-3-phosphate acyltransferase 3, hGPAT3, lung cancer metastasis-associated protein 1, MAG-1, GPAT3, MAG1, HMFN0839, UNQ2753/PRO6492)