17 Beta Hydroxysteroid Dehydrogenase 12

From Anvita Health Wiki

Contents 1 Function 2 Compartment 3 Expression 4 More General Terms 5 Internet Database 6 References

Function

• biosynthesis of estrogens
• fatty acid biosynthesis
• catalyzes the transformation of estrone to estradiol (major enzyme responsible for this conversion in women)
• 3-ketoacyl-CoA reductase activity

• reduces both long chain 3-ketoacyl-CoAs & long chain fatty acyl-CoA
• long fatty acid elongation

Compartment

• endoplasmic reticulum membrane

Expression

• expressed in most tissues
• highly expressed in the ovary, breast, expressed in platelets

More General Terms

• 17 beta-hydroxysteroid dehydrogenase
• membrane protein

Internet Database

Prosite: [1]
UniProt: [2]

References

UniProt [3]

17-beta-hydroxysteroid dehydrogenase 12 (estradiol 17-beta-dehydrogenase 12, 17-beta-HSD 12, 3-ketoacyl-CoA reductase, KAR, HSD17B12)