11 Beta Hydroxysteroid Dehydrogenase 1

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Expression 5 Pathology 6 More General Terms 7 Internet Database 8 References

Function

• catalyzes reversibly conversion of cortisol to inactive metabolite cortisone
• catalyzes conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol; in intact cells, reaction runs only in one direction ( putative)
  

• 11-beta-hydroxysteroid + NADP+ <--> 11-oxosteroid + NADPH

Structure

• homodimer ( putative)
• glycosylated
• belongs to the short-chain dehydrogenases/ reductases (SDR) family

Compartment

• endoplasmic reticulum membrane

Expression

• widely expressed
• ighest expression in liver

Pathology

• defects in HSD11B1 are a cause of cortisone reductase deficiency

More General Terms

• 11-OH steroid dehydrogenase
• membrane protein
• glycoprotein

Internet Database

OMIM: 600713
OMIM: 604931
Prosite: [1]
UniProt: [2]

References

UniProt [3]

11-beta hydroxysteroid dehydrogenase-1 (corticosteroid 11-beta-dehydrogenase isozyme 1, 11-DH, 11-beta-HSD1, HSD11B1, HSD11, HSD11L)